Filariasis and erisipela in Santo Domingo.
Identifieur interne : 00B118 ( Main/Exploration ); précédent : 00B117; suivant : 00B119Filariasis and erisipela in Santo Domingo.
Auteurs : A L Vincent [États-Unis] ; C A Ure A Rojas ; E M Ayoub ; E A Ottesen ; E G HardenSource :
- The Journal of parasitology [ 0022-3395 ] ; 1998.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antibactériens (sang), Anticorps antihelminthe (sang), Désoxyribonucléases (immunologie), Femelle, Filariose lymphatique (), Filariose lymphatique (immunologie), Filariose lymphatique (épidémiologie), Humains, Immunoglobuline G (sang), Lymphadénite (étiologie), Lymphangite (étiologie), Lymphoedème (étiologie), Mâle, Protéines bactériennes, République dominicaine (épidémiologie), Streptococcus (immunologie), Streptolysines (immunologie), Sujet âgé, Test ELISA, Wuchereria bancrofti (immunologie), Érysipèle (), Érysipèle (immunologie), Érysipèle (épidémiologie).
- MESH :
- immunologie : Désoxyribonucléases, Filariose lymphatique, Streptococcus, Streptolysines, Wuchereria bancrofti, Érysipèle.
- sang : Anticorps antibactériens, Anticorps antihelminthe, Immunoglobuline G.
- épidémiologie : Filariose lymphatique, République dominicaine, Érysipèle.
- étiologie : Lymphadénite, Lymphangite, Lymphoedème.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Filariose lymphatique, Humains, Mâle, Protéines bactériennes, Sujet âgé, Test ELISA, Érysipèle.
- Wicri :
- geographic : République dominicaine.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antibodies, Bacterial (blood), Antibodies, Helminth (blood), Bacterial Proteins, Deoxyribonucleases (immunology), Dominican Republic (epidemiology), Elephantiasis, Filarial (complications), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay, Erysipelas (complications), Erysipelas (epidemiology), Erysipelas (immunology), Female, Humans, Immunoglobulin G (blood), Lymphadenitis (etiology), Lymphangitis (etiology), Lymphedema (etiology), Male, Middle Aged, Streptococcus (immunology), Streptolysins (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , blood : Antibodies, Bacterial, Antibodies, Helminth, Immunoglobulin G.
- chemical , immunology : Deoxyribonucleases, Streptolysins.
- geographic , epidemiology : Dominican Republic.
- complications : Elephantiasis, Filarial, Erysipelas.
- epidemiology : Elephantiasis, Filarial, Erysipelas.
- etiology : Lymphadenitis, Lymphangitis, Lymphedema.
- immunology : Elephantiasis, Filarial, Erysipelas, Streptococcus, Wuchereria bancrofti.
- Adolescent, Adult, Aged, Animals, Bacterial Proteins, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged.
Abstract
This study examined acute-convalescent changes in diagnostic anti-streptococcal antibodies by the anti-streptolysin O (ASO) and anti-DNAase B (ADAB) tests among patients (n 28) with lymphedema and recurrent erisipela of the lower limb, comparing them with endemic normal control residents (n=25). The study was based in Villa Francisca, an urban focus of Bancroftian filariasis in eastern Santo Domingo, capital of the Dominican Republic. The acute signs and symptoms of erisipela were consistent with a diagnosis of bacterial cellulitis. The ASO test was especially successful at demonstrating a rise in mean titer during convalescence, whereas the ADAB produced about the same frequency of significant increases (0.2 log titer) as did the ASO. When subjects were scored as responders if mounting a minimal titer increase by either test, patients were found more frequently positive than were controls (chi2=5.3, P=0.02). About half (54%) of all patients mounted at least a minimal antibody increase. Filaria-specific IgG4 antibodies were absent from all sera of 20 residents of a nonendemic Dominican mountain town but appeared in about two-thirds of the sampled residents of the endemic barrio. Notably however, levels did not change between the acute phase and convalescence. These findings are consistent with the hypothesis that recurrent streptococcal invasion of the lymphatics may be a significant factor triggering or amplifying lymphedema and elephantiasis in patients with chronic filariasis.
PubMed: 9645857
Affiliations:
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sortKey="Ayoub, E M" sort="Ayoub, E M" uniqKey="Ayoub E" first="E M" last="Ayoub">E M Ayoub</name></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author><author><name sortKey="Harden, E G" sort="Harden, E G" uniqKey="Harden E" first="E G" last="Harden">E G Harden</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9645857</idno><idno type="pmid">9645857</idno><idno type="wicri:Area/PubMed/Corpus">004E74</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004E74</idno><idno type="wicri:Area/PubMed/Curation">004E74</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004E74</idno><idno type="wicri:Area/PubMed/Checkpoint">004E74</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004E74</idno><idno 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scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Antibodies, Bacterial (blood)</term><term>Antibodies, Helminth (blood)</term><term>Bacterial Proteins</term><term>Deoxyribonucleases (immunology)</term><term>Dominican Republic (epidemiology)</term><term>Elephantiasis, Filarial (complications)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Erysipelas (complications)</term><term>Erysipelas (epidemiology)</term><term>Erysipelas (immunology)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Lymphadenitis (etiology)</term><term>Lymphangitis (etiology)</term><term>Lymphedema (etiology)</term><term>Male</term><term>Middle Aged</term><term>Streptococcus (immunology)</term><term>Streptolysins (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antibactériens (sang)</term><term>Anticorps antihelminthe (sang)</term><term>Désoxyribonucléases (immunologie)</term><term>Femelle</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Lymphadénite (étiologie)</term><term>Lymphangite (étiologie)</term><term>Lymphoedème (étiologie)</term><term>Mâle</term><term>Protéines bactériennes</term><term>République dominicaine (épidémiologie)</term><term>Streptococcus (immunologie)</term><term>Streptolysines (immunologie)</term><term>Sujet âgé</term><term>Test ELISA</term><term>Wuchereria bancrofti (immunologie)</term><term>Érysipèle ()</term><term>Érysipèle (immunologie)</term><term>Érysipèle (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Bacterial</term><term>Antibodies, Helminth</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Deoxyribonucleases</term><term>Streptolysins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Dominican Republic</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Erysipelas</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Erysipelas</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphadenitis</term><term>Lymphangitis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Désoxyribonucléases</term><term>Filariose lymphatique</term><term>Streptococcus</term><term>Streptolysines</term><term>Wuchereria bancrofti</term><term>Érysipèle</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Erysipelas</term><term>Streptococcus</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antibactériens</term><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>République dominicaine</term><term>Érysipèle</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphadénite</term><term>Lymphangite</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Bacterial Proteins</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Filariose lymphatique</term><term>Humains</term><term>Mâle</term><term>Protéines bactériennes</term><term>Sujet âgé</term><term>Test ELISA</term><term>Érysipèle</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République dominicaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study examined acute-convalescent changes in diagnostic anti-streptococcal antibodies by the anti-streptolysin O (ASO) and anti-DNAase B (ADAB) tests among patients (n 28) with lymphedema and recurrent erisipela of the lower limb, comparing them with endemic normal control residents (n=25). The study was based in Villa Francisca, an urban focus of Bancroftian filariasis in eastern Santo Domingo, capital of the Dominican Republic. The acute signs and symptoms of erisipela were consistent with a diagnosis of bacterial cellulitis. The ASO test was especially successful at demonstrating a rise in mean titer during convalescence, whereas the ADAB produced about the same frequency of significant increases (0.2 log titer) as did the ASO. When subjects were scored as responders if mounting a minimal titer increase by either test, patients were found more frequently positive than were controls (chi2=5.3, P=0.02). About half (54%) of all patients mounted at least a minimal antibody increase. Filaria-specific IgG4 antibodies were absent from all sera of 20 residents of a nonendemic Dominican mountain town but appeared in about two-thirds of the sampled residents of the endemic barrio. Notably however, levels did not change between the acute phase and convalescence. These findings are consistent with the hypothesis that recurrent streptococcal invasion of the lymphatics may be a significant factor triggering or amplifying lymphedema and elephantiasis in patients with chronic filariasis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><noCountry><name sortKey="Ayoub, E M" sort="Ayoub, E M" uniqKey="Ayoub E" first="E M" last="Ayoub">E M Ayoub</name><name sortKey="Harden, E G" sort="Harden, E G" uniqKey="Harden E" first="E G" last="Harden">E G Harden</name><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name><name sortKey="Ure A Rojas, C A" sort="Ure A Rojas, C A" uniqKey="Ure A Rojas C" first="C A" last="Ure A Rojas">C A Ure A Rojas</name></noCountry><country name="États-Unis"><region name="Floride"><name sortKey="Vincent, A L" sort="Vincent, A L" uniqKey="Vincent A" first="A L" last="Vincent">A L Vincent</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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